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研究员，云南大学学术学科带头人。
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Laboratory for Conservation and Utilization of Bio-resources
Yunnan University
Kunming 650091
Yunnan, China
Tel.: 86 871-65032538:
Fax: 86 871- 65034838; E-mail: xmniu@ynu.edu.cn |
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教育和工作经历
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1989年9月-1996年7月, 广西师范大学化学系, 学士/硕士 |
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1996年8月-1999年2月, 广西师范大学化学化工系, 讲师, 有机化学 |
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1999年3月-2001年12月, 中国科学院昆明植物研究所, 获理学博士, 植物化学 |
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2002年1月-2004年2月, 中国科学院昆明植物研究所, 助理研究员/副研究员, 植物化学, 天然产物化学 |
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2004年3月- 2004年9月, 香港中文大学中医学院, 博士后, 高等真菌次生代谢产物 |
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2004年10月-2006年3月, 德国莱布尼兹天然产物及感染生物学研究所生物有机化学系, DAAD-Leibniz博士后, 微生物次生代谢产物 |
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2006年4月-2007年7月, 德国马普化学生态研究所生物化学系, 博士后, 化学生态学 |
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2007年11月--, 云南大学生物资源保护与利用重点实验室, 研究员, 次生代谢产物及功能 | |
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EDUCATION AND EXPERIENCE:
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09/1989-07/1996, Studies of Chemistry at Department of Chemistry, Guangxi Normal University, China:
Master’s thesis on 'synthesis of allantoin’ |
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07/1996-03/1999, Lecturer at Department of Chemistry, Guangxi Normal University, Guilin, China |
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03/1999-12/2001, PhD thesis at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences |
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01/2002-06/2003, Assistant Professor at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences |
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07/2003-12/2007, Associate Professor at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences |
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03/2004-09/2004, Postdoctoral Fellow at School of Chinese Medicine, The Chinese University of Hongkong, |
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10/2004-03/2006, Postdoctoral Fellow at Leibniz Institute for Natural Product Research and Infection Biology Hans-Knöll-Institute (HKI),Jena, Germany |
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04/2006-07/2007, Postdoctoral Fellow at Department of Biochemistry, & Research Group Biosynthesis/NMR, Max Planck for Chemical Ecology, Jena, Germany |
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11/2007-present, Professor at Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China | |
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AWARD：
2004.10-2006.3, Postdocoral fellowship by German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD)-Leibniz
主要研究方向：
特境微生物资源的天然产物及生物合成研究
捕食线虫真菌的信号小分子研究
昆虫病原微生物的活性次生代谢产物研究
RESEARCH INTERESTS：
Natural products from microorganisms and plants in Yunnan
Chemical language of nematode-trapping fungi
Bioactive compounds from entomopathgen microorganisms
承担的主要科研项目：
目前承担或参与国家973，863，自然科学基金委、云南省科技厅等在研项目。
欢迎对本组研究方向和工作感兴趣的年青人来实习和以博士后身份来工作，请以E-MAIL联系并附简历。
PUBLICATIONS (2007--):.
1. Luo SH, Hua J, Niu XM, Liu Y, Li CH, Zhou YY, Jing SX, Zhao X, Li SH, Defense sesterterpenoid lactones from Leucosceptrum canum, Phytochemistry, 2013, 86, 29 - 35.
2. Jianlin Tan, Xue-Mei Niu, Guangyu Yang, Lang Wang, Yuanxing Duan, Yi Han, Keqin Zhang, Chengming Zhang. Quantitative Determination of Phytosterols in Tobacco Leaves by UPLC-MS/MS. Journal of Liquid Chromatography & Related Technologies. 2013, 36, 591-599.
3. Ji-Peng Guo, Chun-Yan Zhu, Chuan-Ping Zhang, Yan-Sheng Chu, Yan-Li Wang, Jun-Xian Zhang, De-Kai Wu, Ke-Qin Zhang, Xue-Mei Niu*. Thermolides, Potent Nematocidal PKS-NRPS Hybrid Metabolites from Thermophilic Fungus Talaromyces thermophilus, Journal of the American Chemical Society, 2012, 134(50), 20306-20309. (*corresponding author)
4. Sheng-Hong Li, Nina Elisabeth Nagy, Almuth Hammerbacher, Paal Krokene, Xue-Mei Niu, Jonathan Gershenzon, Bernd Schneider. Localization of Phenolics in Phloem Parenchyma Cells of Norway Spruce (Picea abies), ChemBioChem, 2012, 13(18), 2707 - 2713.
5. Hui-Xiang Zhang, Jian-Lin Tan, Lu-Xia Wei, Yan-Li Wang, Chuan-Ping Zhang, De-Kai Wu, Chun-Yan Zhu, Ying Zhang, Ke-Qin Zhang, Xue-Mei Niu*. Morphology Regulatory Metabolites from Arthrobotrys oligospora. Journal of Natural Products, 2012, 75 (7), 1419-1423. (*corresponding author)
6. Hong-Yang Wu, Yan-Li Wang, Jian-Lin Tan, Chun-Yan Zhu, Dong-Xian Li, Rong-Huang, Ke-Qin Zhang, Xue-Mei Niu*. Regulation of the Growth of Cotton Bollworms by Metabolites from an Entomopathogenic Fungus Paecilomyces cateniobliquus. Journal of Agricultural and Food Chemistry, 2012, 60(22), 5604-5608. (*corresponding author)
7. Shi-Hong Luo, Yan Liu, Juan Hua, Xue-Mei Niu, Shu-Xi Jing, Xu Zhao, Bernd Schneider, Jonathan Gershenzon, Sheng-Hong Li, Unique Proline-Benzoquinone Pigment from the Colored Nectar of "Bird's Coca Cola Tree" Functions in Bird Attractions. Organic Letters, 2012, 14(16), 4146-4149.
8. Li L, Ma MC, Huang R, Qu Q, Li GH, Zhou JW, Zhang KQ, Lu KP, Niu XM, Luo J, Induction of Chlamydospore Formation in Fusarium by Cyclic Lipopeptide Antibiotics from Bacillus subtilis C2. J Chem Ecol, 2012, 38:966-974.
9. Ji-Peng Guo, Jian-Lin Tan, Yan-Li Wang, Hong-Yang Wu, Chuan-Ping Zhang, Xue-Mei Niu*, Wen-Zheng Pan, Xiao-Wei Huang, Ke-Qin Zhang. Isolation of Talathermophilins from a Thermophilic Fungus Talaromyces thermophilus YM3-4. Journal of Natural Products, 2011, 74(10), 2278-2281. (*corresponding author)
10. Lu-Xia Wei, Hui-Xiang Zhang, Jian-Lin Tan, Yan-Sheng Chu, Nan Li, Hua-Xi Xue, Yan-Li Wang, Xue-Mei Niu*, Ying Zhang, Ke-Qin Zhang. Arthrobotrisins A-C, Oligosporons from the Nematode-Trapping Fungus Arthrobotrys oligospora. Journal of Natural Products, 2011, 74(6), 1526-1530. (*corresponding author)
11. Xue-Mei Niu, Ke-Qin Zhang. Arthrobotrys oligospora: a Model Organism for Understanding the Interaction between Fungi and Nematodes. Mycology, 2011, 2(2), 59-78.
12. Qiuhong Niu, Yunxia Tian, Lin Zhang, Xiao’e Xu, Xuemei Niu, Ke-Qin Zhang, Xiaowei Huang. Overexpression of the Key Virulence Proteases Bace16 and Bae16 in Bacillus nematocida B16 to Improve its Nematocidal Activity. Journal of Molecular Microbiology and Biotechnology, 2011, 21, 130-137.
13. Jinkui Yang, Lei Wang, Xinglai Ji, Yun Feng, Xiaomin Li, Chenggang Zou, Jianping Xu, Yan Ren, Qili Mi, Junli Wu, Shuqun Liu, Yu Liu, Xiaowei Huang, Haiyan Wang, Xuemei Niu, Juan Li, Lianming Liang, Yanlu Luo, Kaifang Ji, Wei Zhou, Zefen Yu, Guohong Li, Yajun Liu, Lei Li, Min Qiao, Lu Feng, Ke-Qin Zhang. Genomic and Proteomic Analyses of the Fungus Arthrobotrys oligospora Provide Insights into Nematode-Trap Formation. Plos Pathogens, 2011, 7, e1002179.
14. Jinkui Yang, Xuna Zhao, Lianming Liang , Zhenyuan Xia, Liping Lei, Xuemei Niu, Chenggang Zou, Ke-Qin Zhang. Overexpression of a Cuticle-Degrading Protease Ver112 Increases the Nematicidal Activity of Paecilomyces lilacinus. Applied Microbiology Biotechnology, 2011, 89, 1895-1903.
15. GuoHong Li, ZhongShan Yang, PeiJi Zhao, Xi Zheng, ShaoLiu Luo, Rong Sun, Xuemei Niu, Keqin Zhang. Three new Acorane Sesquiterpenes from Trichoderma sp. YMF1.02647. Phytochemistry Letters, 2011, 4, 86-88.
16. Yan-Sheng Chu, Xue-Mei Niu*, Yan-Li Wang, Ji-Peng Guo, Wen-Zheng Pan, Xiao-Wei Huang, Ke-Qin Zhang. Isolation of Putative Biosynthetic Intermediates of Prenylated Indole Alkaloids from a Thermophilic Fungus Talaromyces thermophilus. Organic Letters, 2010, 12(19), 4356-4359. (*corresponding author)
17. Xue-Mei Niu, Yan-li Wang, Yansheng Chu, Huaxi Xue, Nan Li, Luxia Wei, Minghe Mo, Keqin Zhang. Nematodetoxic Aurovertin-Type Metabolites from a Root-Knot Nematode Parasitic Fungus Pochonia chlamydosporia. Journal of Agricultural and Food Chemistry, 2010, 58(2), 828-834.
18. Chun-Huan Li, Xue-Mei Niu, Qian Luo, Ming-Jin Xie, Shi-Hong Luo, Yan-Ying Zhou, Sheng-Hong Li. Novel Polyesterified 3,4-seco-Grayanane Diterpenoids as Antifeedants from Pieris formosa. Organic Letters, 2010, 12 (10), 2426-2429.
19. Shi-Hong Luo, Qian Luo, Xue-Mei Niu, Ming-Jin Xie, Xu Zhao, Bernd Schneider, Jonathan Gershenzon, Sheng-Hong Li. Glandular Trichomes of Leucosceptrum canum Harbor Defensive Sesterterpenoids. Angewandte Chemie International Edition, 2010, 49, 4471-4475.
20. Qiuhong Niu, Xiaowei Huang, Lin Zhang, Jianping Xu, Dongmei Yang, Kangbi Wei, Xuemei Niu, Zhiqiang An, Joan Wennstrom Bennett, Chenggang Zou, Jinkui Yang, Ke-Qin Zhang. A Trojan Horse Mechanism of Bacterial Pathogenesis against Nematodes. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (38), 16631-16636.
21. Zhong-Shan Yang, Guo-Hong Li, Pei-Ji Zhao, Xi Zheng, Shao-Liu Luo, Lei Li, Xue-Mei Niu, Ke-Qin Zhang. Nematicidal activity of Trichoderma spp. and Isolation of an Active Compound. World Journal of Microbiology and Biotechnology, 2010, 26, 2297-2302.
22. Qili Mi, Jinkui Yang, Fengping Ye, Zhongwei Gan, Changwei Wu, Xuemei Niu, Chenggang Zou, Ke-Qin Zhang. Cloning and over expression of Pochonia chlamydosporia chitinase gene pcchi44, a potential virulence factor in infection against nematodes. Process Biochemistry, 2010, 45(5), 810-814.
23. Xu Zhao, Guowei Zheng, Xuemei Niu, Weiqi Li, Fusheng Wang, Sheng-Hong Li, Terpenes from Eupatorium adenophorum and Their Allelopathic Effects on Arabidopsis Seeds Germination. Journal of Agricultural and Food Chemistry, 2009, 57, 478-482.
24. Xuemei Niu, Hans-Martin Dahse, Klaus-Dieter Menzel, Olivier Lozach, Grit Walther, Laurent Meijer, Susanne Grabley, Isabel Sattler. Butyrolactone I Derivatives from Aspergillus terreus Carrying an Unusual Sulfate Moiety, Journal of Natural Products, 2008, 71, 689-692.
25. Xueshi Huang, Jian He, Xuemei Niu, Klaus-Dieter Menzel, Hans-Martin Dahse, Susanne Grabley, Hans-Peter Fiedler, Isabel Sattler, Christian Hertweck. Benzopyrenomycin, a Cytotoxic Bacterial Polyketide Metabolite with a Benzo[a]pyrene-Type Carbocyclic Ring System. Angewandte Chemie International Edition, 2008, 47, 1-5.
26. Sheng-Hong Li, Xue-Mei Niu, Stefan Zahn, Jonathan Gershenzon, Jennie Weston, Bernd Schneider. Diastereomeric Stilbene Glucoside Dimers from the Bark of Norway Spruce (Picea abies). Phytochemistry, 2008, 69, 772-782.
27. Xuemei Niu, Shenghong Li, Helmar Görls, Dieter Schollmeyer, Matthias Hilliger, Susanne Grabley, Isabel Sattler. Abyssomicin E, a Highly Functionalized Polycyclic Metabolite from Streptomyces species. Organic Letters, 2007, 9(13), 2437-2440.
28. Xuemei Niu, Shenghong Li, Handong Sun, Chuntao Che. Two new Lanostanoids from Ganoderma resinaceum. Journal of Asian Natural Products Research, 2007, 9(7), 659-664.
29. Yu Zhao, Xuemei Niu, Liping Qian, Zeyuan Liu, Qinshi Zhao, Handong Sun. Synthesis and Cytotoxicity of Some new Eriocalyxin B Derivatives. European Journal of Medicinal Chemistry, 2007, 42(4), 494-502.
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